{"id":1366379,"date":"2022-02-14T10:31:34","date_gmt":"2022-02-14T09:31:34","guid":{"rendered":"https:\/\/dnaera.mnt.webikon.sk\/cs\/?p=1366379"},"modified":"2022-09-08T11:47:59","modified_gmt":"2022-09-08T09:47:59","slug":"aktualizace-vysledku-vitamin-d","status":"publish","type":"post","link":"https:\/\/dnaera.mnt.webikon.sk\/cs\/blog\/aktualizace-vysledku-vitamin-d\/","title":{"rendered":"Nov\u00e9 studie spojen\u00e9 s vitam\u00ednem D – aktualizace v\u00fdsledk\u016f"},"content":{"rendered":"\n

V\u011bdeck\u00e9<\/em> pozn\u00e1n\u00ed neust\u00e1le postupuje a v\u00fdjimkou nen\u00ed ani pozn\u00e1v\u00e1n\u00ed lidsk\u00e9 DNA. D\u00edky v\u00fdzkumu p\u0159ich\u00e1z\u00edme na nov\u00e9 asociace mezi rozd\u00edly v sekvenci DNA, kter\u00e9 se p\u0159irozen\u011b vyskytuj\u00ed mezi lidmi a interpretovateln\u00fdmi znaky. Dok\u00e1\u017eeme tak ur\u010dit rizika rozvoje n\u011bkter\u00fdch onemocn\u011bn\u00ed nebo predispozice k hladin\u011b vitam\u00ednu v na\u0161\u00ed krvi. Nov\u00e9 v\u011bdeck\u00e9 studie zp\u0159es\u0148uj\u00ed predispozice spojen\u00e9 s hladinou vitam\u00ednu D v krvi. Pro na\u0161e z\u00e1kazn\u00edky jsme proto p\u0159ipravili aktualizaci v\u00fdsledk\u016f. <\/em><\/p>\n\n\n\n

Do vyhodnocov\u00e1n\u00ed jsme zapracovali 3 nov\u00e9 studie<\/h2>\n\n\n\n

V souvislosti s hladinou vitam\u00ednu D v krvi byly v ned\u00e1vn\u00e9 dob\u011b publikov\u00e1ny 3 rozs\u00e1hl\u00e9 studie. V nich v\u011bdci porovn\u00e1vali re\u00e1ln\u00e9 hladiny vitam\u00ednu D v krvi s rozd\u00edly na \u00farovni DNA, a to na vzorku n\u011bkolika set tis\u00edc lid\u00ed. D\u00edky t\u011bmto studi\u00edm bylo objeven\u00fdch v\u00edcero genetick\u00fdch variant, kter\u00e9 statisticky v\u00fdznamn\u011b koreluj\u00ed s hladinou vitam\u00ednu D v krvi.<\/p>\n\n\n\n

Ve v\u0161ech t\u011bchto studi\u00edch byl vyu\u017eit p\u0159\u00edstup tzv. celogenomov\u00e9 asocia\u010dn\u00ed studie (z angl. Genome-wide Association Study, GWAS), kter\u00fd je vhodn\u00fd pr\u00e1v\u011b k odhalen\u00ed v populaci b\u011b\u017en\u00fdch genetick\u00fdch variant, kter\u00e9 v\u011bt\u0161inou samy o sob\u011b nemaj\u00ed velk\u00fd vliv na sledovan\u00e9 vlastnosti, av\u0161ak kdy\u017e se jich nasb\u00edr\u00e1 v\u00edce, jejich v\u00fdsledn\u00fd efekt m\u016f\u017ee b\u00fdt v\u00fdznamn\u00fd.<\/p>\n\n\n\n

Na z\u00e1klad\u011b nov\u00fdch studi\u00ed jsme p\u0159istoupili k aktualizaci na\u0161eho interpreta\u010dn\u00edho softwaru a upravili algoritmus vyhodnocuj\u00edc\u00ed genetickou predispozici ke hladin\u011b vitam\u00ednu D u v\u0161ech na\u0161ich existuj\u00edc\u00edch z\u00e1kazn\u00edk\u016f, kte\u0159\u00ed m\u011bli zakoupen\u00fd DNA Complex nebo DNA Lifestyle test. V\u00fdsledky budou automaticky upraveny i t\u011bm, kte\u0159\u00ed pr\u00e1v\u011b \u010dekaj\u00ed na v\u00fdsledky sv\u00e9 anal\u00fdzy DNA. V\u011b\u0159\u00edme toti\u017e, \u017ee v\u00fdsledky na\u0161ich z\u00e1kazn\u00edk\u016f by m\u011bly reflektovat aktu\u00e1ln\u00ed v\u011bdeck\u00e9 pozn\u00e1n\u00ed v dan\u00e9 oblasti, a to i za cenu toho, \u017ee se mohou \u010dasem zm\u011bnit.<\/strong><\/p>\n\n\n\n

Jak vn\u00edm\u00e1 \u00falohu vitam\u00ednu D v t\u011ble nutri\u010dn\u00ed expertka Petronela Fori\u0161ek Paulov\u00e1<\/h2>\n\n\n\n

Vitam\u00edn D je nezbytn\u00fd pro prevenci onemocn\u011bn\u00ed souvisej\u00edc\u00edch s nedostate\u010dnou mineralizac\u00ed kost\u00ed. Do t\u011bla se m\u016f\u017ee dostat bu\u010f prost\u0159ednictv\u00edm v\u00fd\u017eivy, nebo m\u016f\u017ee b\u00fdt vytvo\u0159en v k\u016f\u017ei vlivem slune\u010dn\u00edho z\u00e1\u0159en\u00ed. V p\u0159\u00edpad\u011b, \u017ee je tvorba vitam\u00ednu D prost\u0159ednictv\u00edm slune\u010dn\u00edho z\u00e1\u0159en\u00ed omezen\u00e1, o to d\u016fle\u017eit\u011bj\u0161\u00ed je db\u00e1t na p\u0159\u00edjem vitam\u00ednu ve strav\u011b. B\u011bhem zimn\u00edch m\u011bs\u00edc\u016f, nebo v p\u0159\u00edpad\u011b st\u0159\u00eddm\u00e9 konzumace ryb a ryb\u00edch v\u00fdrobk\u016f je vhodn\u00e9 zv\u00e1\u017eit i v\u00fd\u017eivov\u00fd dopln\u011bk obsahuj\u00edc\u00ed vitam\u00edn D.<\/p>\n\n\n\n

\"Zdroje<\/figure>\n\n\n\n

Udr\u017eovat si p\u0159ehled je pro n\u00e1s prioritou <\/h2>\n\n\n\n

N\u00e1\u0161 genetick\u00fd t\u00fdm neust\u00e1le sleduje v\u011bdeck\u00fd pokrok v ch\u00e1p\u00e1n\u00ed souvislost\u00ed rozd\u00edl\u016f na \u00farovni DNA se v\u0161emi vlastnostmi, kter\u00e9 jsou u\u017e dnes sou\u010d\u00e1st\u00ed na\u0161eho testu DNA. D\u00edky tomu m\u016f\u017eeme p\u0159in\u00e1\u0161et nejaktu\u00e1ln\u011bj\u0161\u00ed v\u00fdsledky pro na\u0161e nov\u00e9, ale i u\u017e existuj\u00edc\u00ed z\u00e1kazn\u00edky. Aktualizace v\u00fdsledk\u016f prov\u00e1d\u00edme pravideln\u011b a o tomto kroku informujeme v\u0161echny z\u00e1kazn\u00edky, hned jakmile jsou v\u00fdsledky dostupn\u00e9 ve webov\u00e9 aplikaci.<\/strong><\/p>\n\n\n\n

Nahl\u00e9dn\u011bte do va\u0161ich v\u00fdsledk\u016f<\/h2>\n\n\n\n

Zm\u011bnil se v\u00e1\u0161 v\u00fdsledek t\u00fdkaj\u00edc\u00ed se genetick\u00e9 predispozice ke hladin\u011b vitam\u00ednu D v krvi d\u00edky nov\u011b objeven\u00fdm genetick\u00fdm variant\u00e1m? Zjistit to je velmi jednoduch\u00e9, p\u0159ihlaste se do sv\u00e9ho \u00fa\u010dtu v na\u0161\u00ed webov\u00e9 aplikaci<\/a>, kde ji\u017e od t\u00e9to chv\u00edle najdete v\u00fdsledek, kter\u00fd reflektuje nejaktu\u00e1ln\u011bj\u0161\u00ed v\u011bdeck\u00e9 pozn\u00e1n\u00ed v t\u00e9to oblasti. Naposledy jsme na\u0161im z\u00e1kazn\u00edk\u016fm p\u0159idali \u00fapln\u011b nov\u00fa vlastnost<\/a>, kter\u00e1 nebyla sou\u010d\u00e1st\u00ed anal\u00fdzy v dob\u011b, kdy si test kupovali.<\/p>\n\n\n\n

Pokud je\u0161t\u011b nem\u00e1te sv\u016fj test<\/a>, mo\u017en\u00e1 pr\u00e1v\u011b toto je jeden z d\u016fvod\u016f, kter\u00fd v\u00e1m pom\u016f\u017ee rozhodnout se. Nejen\u017ee od n\u00e1s dostanete rozs\u00e1hlou anal\u00fdzu sv\u00fdch predispozic i s doporu\u010den\u00edmi v r\u00e1mci prevence, ale va\u0161e v\u00fdsledky budeme neust\u00e1le aktualizovat, aby byly v\u017edy v souladu s nejnov\u011bj\u0161\u00edmi v\u011bdeck\u00fdmi poznatky.<\/p>\n\n\n\n

\"DNA<\/a><\/figure>\n\n\n\n

Zdroje: <\/strong><\/p>\n\n\n\n

  1. Manousaki, D., Mitchell, R., Dudding, T., Haworth, S., Harroud, A., Forgetta, V., … & Richards, J. B. (2020). Genome-wide association study for vitamin D levels reveals 69 independent loci. The American Journal of Human Genetics, 106(3), 327-337.<\/li>
  2. Revez, J. A., Lin, T., Qiao, Z., Xue, A., Holtz, Y., Zhu, Z., … & McGrath, J. J. (2020). Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration. Nature communications, 11(1), 1-12.<\/li>
  3. Sinnott-Armstrong, N., Tanigawa, Y., Amar, D., Mars, N., Benner, C., Aguirre, M., … & Rivas, M. A. (2021). Genetics of 35 blood and urine biomarkers in the UK Biobank. Nature genetics, 53(2), 185-194.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"

    V\u011bdeck\u00e9 pozn\u00e1n\u00ed neust\u00e1le postupuje a v\u00fdjimkou nen\u00ed ani pozn\u00e1v\u00e1n\u00ed lidsk\u00e9 DNA. D\u00edky v\u00fdzkumu p\u0159ich\u00e1z\u00edme na nov\u00e9 asociace mezi rozd\u00edly v sekvenci DNA, kter\u00e9 se p\u0159irozen\u011b vyskytuj\u00ed mezi lidmi a interpretovateln\u00fdmi znaky. Dok\u00e1\u017eeme tak ur\u010dit rizika rozvoje n\u011bkter\u00fdch onemocn\u011bn\u00ed nebo predispozice k hladin\u011b vitam\u00ednu v na\u0161\u00ed krvi. Nov\u00e9 v\u011bdeck\u00e9 studie zp\u0159es\u0148uj\u00ed predispozice spojen\u00e9 s hladinou vitam\u00ednu […]<\/p>\n","protected":false},"author":6,"featured_media":1366380,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[33],"tags":[58,59],"place-taxonomy":[],"class_list":["post-1366379","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-cs","tag-dna-analyza","tag-dna-test"],"acf":[],"views":1043,"_links":{"self":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1366379","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/comments?post=1366379"}],"version-history":[{"count":5,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1366379\/revisions"}],"predecessor-version":[{"id":1366408,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1366379\/revisions\/1366408"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/media\/1366380"}],"wp:attachment":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/media?parent=1366379"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/categories?post=1366379"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/tags?post=1366379"},{"taxonomy":"place-taxonomy","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/place-taxonomy?post=1366379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}