{"id":1373729,"date":"2023-09-12T10:48:36","date_gmt":"2023-09-12T08:48:36","guid":{"rendered":"https:\/\/dnaera.mnt.webikon.sk\/cs\/?p=1373729"},"modified":"2023-12-18T10:19:32","modified_gmt":"2023-12-18T09:19:32","slug":"ibuprofen","status":"publish","type":"post","link":"https:\/\/dnaera.mnt.webikon.sk\/cs\/blog\/ibuprofen\/","title":{"rendered":"Ne\u017e\u00e1douc\u00ed \u00fa\u010dinky p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed ibuprofenu ovliv\u0148uj\u00ed tak\u00e9 geny"},"content":{"rendered":"\n<p><em>Ibuprofen je l\u00e9k, kter\u00fd se nach\u00e1z\u00ed t\u00e9m\u011b\u0159 v ka\u017ed\u00e9 dom\u00e1cnosti. V\u011bd\u011bli jste ale, \u017ee na jeho nep\u0159\u00edzniv\u00e9 \u00fa\u010dinky maj\u00ed vliv i va\u0161e geny? Do v\u00fdsledk\u016f anal\u00fdzy DNA jsme p\u0159idali novou predispozici, kter\u00e1 v\u00e1m umo\u017en\u00ed zjistit, zda m\u00e1te predispozici ke standardn\u00edmu, slab\u0161\u00edmu nebo slab\u00e9mu metabolismu ibuprofenu.&nbsp;<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Na jak\u00e9 pot\u00ed\u017ee se l\u00e9k pou\u017e\u00edv\u00e1?<strong>&nbsp;<\/strong><\/h2>\n\n\n\n<p>Ibuprofen je zn\u00e1m\u00fd jako l\u00e9k na tlumen\u00ed bolesti, potla\u010den\u00ed z\u00e1n\u011btu a sni\u017eov\u00e1n\u00ed hore\u010dky. L\u00e9ka\u0159i jej tak\u00e9 p\u0159edepisuj\u00ed jako dlouhodobou l\u00e9\u010dbu revmatoidn\u00ed artritidy, osteoartr\u00f3zy a dal\u0161\u00edch chronick\u00fdch onemocn\u011bn\u00ed.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh6.googleusercontent.com\/aycUTx4zdAwwHd0QHRgS5yooC92uPRc7eHFoSAcEtcRzCQXRxXkXdJMezR5aynhK_QkNuvvtAVHrX1OQjKZ5INPqTcYyuKcxG0QCEUnKoO4oBcYVeEbtI_h3ag_AzSrh7A8ySqO93VhtP0c6JEz4Q2s\" alt=\"\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Co ovliv\u0148uje, jak\u00fd jste metaboliz\u00e9r?&nbsp;<\/h2>\n\n\n\n<p>V souvislosti s metabolismem ibuprofenu, ale i jin\u00fdch l\u00e9\u010div, se b\u011b\u017en\u011b pou\u017e\u00edvaj\u00ed term\u00edny<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>standardn\u00ed metaboliz\u00e9r,&nbsp;<\/li>\n\n\n\n<li>slab\u0161\u00ed metaboliz\u00e9r,<\/li>\n\n\n\n<li>slab\u00fd metaboliz\u00e9r.<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>Geny CYP2C9 a CYP2C8 zaji\u0161\u0165uj\u00ed produkci enzym\u016f, kter\u00e9 jsou kl\u00ed\u010dov\u00e9 pro odstra\u0148ov\u00e1n\u00ed ibuprofenu z organismu. Kv\u016fli sn\u00ed\u017een\u00e9, p\u0159\u00edpadn\u011b chyb\u011bj\u00edc\u00ed aktivit\u011b t\u011bchto enzym\u016f u m\u00edrn\u011b slab\u0161\u00edch nebo slab\u00fdch metaboliz\u00e9r\u016f ibuprofenu z\u016fst\u00e1v\u00e1 l\u00e9\u010divo v t\u011ble d\u00e9le. To zvy\u0161uje riziko rozvoje ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f a toxicity.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Jak\u00e1 je v\u00fdhoda znalosti genetick\u00fdch predispozic?<\/h2>\n\n\n\n<p>Znalost predispozice spojen\u00e9 s metabolismem l\u00e9\u010diva je d\u016fle\u017eitou informac\u00ed pro l\u00e9ka\u0159e nebo l\u00e9k\u00e1rn\u00edka, se kter\u00fdmi se rad\u00edte o l\u00e9\u010db\u011b. Mohou v\u00e1m doporu\u010dit jin\u00e9 mo\u017enosti l\u00e9\u010dby, zejm\u00e9na pokud:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>m\u00e1te nebo jste m\u011bli v\u0159edy, p\u0159\u00edpadn\u011b krv\u00e1cen\u00ed do tr\u00e1vic\u00edho traktu,&nbsp;<\/li>\n\n\n\n<li>m\u00e1te nebo jste m\u011bli kardiovaskul\u00e1rn\u00ed onemocn\u011bn\u00ed,&nbsp;<\/li>\n\n\n\n<li>trp\u00edte astmatem nebo alergiemi,&nbsp;<\/li>\n\n\n\n<li>p\u0159\u00edpadn\u011b pokud trp\u00edte jin\u00fdmi zdravotn\u00edmi komplikacemi, kter\u00e9 jsou uvedeny ve v\u00fdsledc\u00edch anal\u00fdzy DNA.&nbsp;<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Nov\u00e1 predispozice je ji\u017e ve va\u0161\u00ed anal\u00fdze<\/h2>\n\n\n\n<p><strong>P\u0159ihlaste se ke sv\u00e9mu \u00fa\u010dtu<\/strong> ve webov\u00e9 aplikaci a pod\u00edvejte se na sv\u00e9 v\u00fdsledky. Nov\u00e1 predispozice byla automaticky zdarma p\u0159id\u00e1na v\u0161em na\u0161im st\u00e1vaj\u00edc\u00edm z\u00e1kazn\u00edk\u016fm. Budouc\u00ed z\u00e1kazn\u00edci najdou tuto predispozici v <a href=\"https:\/\/dnaera.mnt.webikon.sk\/cs\/produkt\/dna-complex-test\/\">DNA Complex testu<\/a> a <a href=\"https:\/\/dnaera.mnt.webikon.sk\/cs\/produkt\/dna-health-test\/\">DNA Health testu<\/a>. Zn\u00e1t svoje geny m\u00e1 smysl v ka\u017ed\u00e9m v\u011bku. \u010c\u00edm d\u0159\u00edv, t\u00edm l\u00e9pe. Za\u010dn\u011bte objevovat svoji DNA i vy.&nbsp;<\/p>\n\n\n\n<p><strong>Zdroje:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nhs.uk\/medicines\/ibuprofen-for-adults\/who-can-and-cannot-take-ibuprofen\/\">https:\/\/www.nhs.uk\/medicines\/ibuprofen-for-adults\/who-can-and-cannot-take-ibuprofen\/<\/a><\/li>\n\n\n\n<li>Mazaleuskaya, L. L., Theken, K. N., Gong, L., Thorn, C. F., Fitzgerald, G. A., Altman, R. B., &amp; Klein, T. E. (2015). PharmGKB summary: ibuprofen pathways. Pharmacogenetics and genomics, 25(2), 96.<\/li>\n<\/ol>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>Zdroje fotografi\u00ed:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.pexels.com\/photo\/woman-holding-half-full-glass-and-white-medicine-pill-576831\/\">https:\/\/www.pexels.com\/photo\/woman-holding-half-full-glass-and-white-medicine-pill-576831\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Ibuprofen je l\u00e9k, kter\u00fd se nach\u00e1z\u00ed t\u00e9m\u011b\u0159 v ka\u017ed\u00e9 dom\u00e1cnosti. V\u011bd\u011bli jste ale, \u017ee na jeho nep\u0159\u00edzniv\u00e9 \u00fa\u010dinky maj\u00ed vliv i va\u0161e geny? Do v\u00fdsledk\u016f anal\u00fdzy DNA jsme p\u0159idali novou predispozici, kter\u00e1 v\u00e1m umo\u017en\u00ed zjistit, zda m\u00e1te predispozici ke standardn\u00edmu, slab\u0161\u00edmu nebo slab\u00e9mu metabolismu ibuprofenu.&nbsp; Na jak\u00e9 pot\u00ed\u017ee se l\u00e9k pou\u017e\u00edv\u00e1?&nbsp; Ibuprofen je zn\u00e1m\u00fd jako [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":1373730,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[58,59],"place-taxonomy":[],"class_list":["post-1373729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-sk","tag-dna-analyza","tag-dna-test"],"acf":[],"views":198,"_links":{"self":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1373729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/comments?post=1373729"}],"version-history":[{"count":5,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1373729\/revisions"}],"predecessor-version":[{"id":1375000,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1373729\/revisions\/1375000"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/media\/1373730"}],"wp:attachment":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/media?parent=1373729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/categories?post=1373729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/tags?post=1373729"},{"taxonomy":"place-taxonomy","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/place-taxonomy?post=1373729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}