{"id":1380579,"date":"2024-08-19T15:31:20","date_gmt":"2024-08-19T13:31:20","guid":{"rendered":"https:\/\/dnaera.mnt.webikon.sk\/cs\/?p=1380579"},"modified":"2024-10-16T11:33:19","modified_gmt":"2024-10-16T09:33:19","slug":"thioguanin-maly-bojovnik-jehoz-silu-ovlivnuji-geny","status":"publish","type":"post","link":"https:\/\/dnaera.mnt.webikon.sk\/cs\/blog\/thioguanin-maly-bojovnik-jehoz-silu-ovlivnuji-geny\/","title":{"rendered":"Thioguanin \u2013 mal\u00fd bojovn\u00edk, jeho\u017e s\u00edlu ovliv\u0148uj\u00ed geny"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>Dok\u00e1\u017eete si p\u0159edstavit molekulu tak malou, \u017ee ji nevid\u00edte, ale tak silnou, \u017ee dok\u00e1\u017ee zm\u011bnit \u017eivot pacienta s onkologick\u00fdm onemocn\u011bn\u00edm? Thioguanin je p\u0159esn\u011b takovou molekulou \u2013 nen\u00e1padn\u00fd a \u00fa\u010dinn\u00fd hrdina v boji proti rakovin\u011b. Abychom v\u0161ak zajistili jeho maxim\u00e1ln\u00ed \u00fa\u010dinnost a minimalizovali riziko ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f, je nezbytn\u00e9 pochopit, jak p\u0159\u00edtomnost r\u016fzn\u00fdch genetick\u00fdch variant v na\u0161\u00ed DNA ovliv\u0148uje jeho metabolismus.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong>O jak\u00e9 l\u00e9\u010divo jde a jak \u00fa\u010dinkuje?\u00a0<\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Thioguanin je syntetick\u00e9 l\u00e9\u010divo pat\u0159\u00edc\u00ed do skupiny thiopurin\u016f se schopnost\u00ed p\u016fsobit proti n\u00e1dor\u016fm a potla\u010dovat imunitn\u00ed syst\u00e9m. D\u00edky sv\u00e9 molekul\u00e1rn\u00ed struktu\u0159e p\u016fsob\u00ed na \u00farovni DNA t\u00edm, \u017ee zabra\u0148uje synt\u00e9ze nukleov\u00fdch kyselin, co\u017e vede k zastaven\u00ed d\u011blen\u00ed rakovinn\u00fdch bun\u011bk. Tento proces efektivn\u011b naru\u0161uje jejich schopnost mno\u017eit se, \u010d\u00edm\u017e p\u0159isp\u00edv\u00e1 k jejich postupn\u00e9mu zni\u010den\u00ed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong>Na co se pou\u017e\u00edv\u00e1?\u00a0<\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">D\u00edky sv\u00e9 schopnosti c\u00edlit a eliminovat rychle se d\u011bl\u00edc\u00ed bu\u0148ky se thioguanin vyu\u017e\u00edv\u00e1 p\u0159edev\u0161\u00edm p\u0159i l\u00e9\u010db\u011b onkologick\u00fdch onemocn\u011bn\u00ed, konkr\u00e9tn\u011b akutn\u00ed myeloidn\u00ed leuk\u00e9mie.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong>Na co se pou\u017e\u00edv\u00e1?\u00a0<\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">V souvislosti s metabolismem thioguaninu, ale i jin\u00fdch l\u00e9\u010div, se b\u011b\u017en\u011b pou\u017e\u00edvaj\u00ed pojmy:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>standardn\u00ed metaboliz\u00e9r,<\/li>\n\n\n\n<li>slab\u0161\u00ed metaboliz\u00e9r,<\/li>\n\n\n\n<li>slab\u00fd metaboliz\u00e9r.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Thioguanin je prol\u00e9\u010divo, kter\u00e9 se po vstupu do bun\u011bk p\u0159em\u011b\u0148uje na aktivn\u00ed metabolity schopn\u00e9 p\u016fsobit na rakovinn\u00e9 bu\u0148ky za\u010dlen\u011bn\u00edm do DNA. A\u010dkoli jsou tyto aktivn\u00ed metabolity \u00fa\u010dinn\u00e9 v boji proti rakovin\u011b, mohou b\u00fdt z\u00e1rove\u0148 toxick\u00e9 pro zdrav\u00e9 bu\u0148ky a vyvolat tak ne\u017e\u00e1douc\u00ed \u00fa\u010dinky. Geny TPMT a NUDT15 zaji\u0161\u0165uj\u00ed tvorbu enzym\u016f d\u016fle\u017eit\u00fdch p\u0159i inaktivaci t\u011bchto toxick\u00fdch metabolit\u016f ve snaze zajistit rovnov\u00e1hu mezi \u00fa\u010dinnost\u00ed l\u00e9\u010diva a jeho toxicitou. P\u0159\u00edtomnost ur\u010dit\u00fdch genetick\u00fdch variant v t\u011bchto genech m\u00e1 za n\u00e1sledek tvorbu enzym\u016f se sn\u00ed\u017eenou, p\u0159\u00edpadn\u011b chyb\u011bj\u00edc\u00ed aktivitou, \u010d\u00edm\u017e se u pacienta zvy\u0161uje riziko rozvoje ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f a toxicity.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong>Jak\u00e1 je v\u00fdhoda znalosti genetick\u00e9 predispozice?\u00a0<\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Znalost genetick\u00e9 predispozice pro metabolismus thioguaninu je d\u016fle\u017eitou informac\u00ed pro l\u00e9ka\u0159e \u010di l\u00e9k\u00e1rn\u00edka, s nimi\u017e v p\u0159\u00edpad\u011b pot\u0159eby m\u016f\u017eete l\u00e9pe a rychleji optimalizovat u\u017e\u00edv\u00e1n\u00ed tohoto l\u00e9\u010diva a p\u0159edch\u00e1zet tak vzniku ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"358\" src=\"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-content\/uploads\/sites\/3\/2024\/08\/CZ-tiog-1024x358.png\" alt=\"\" class=\"wp-image-1380580\" srcset=\"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-content\/uploads\/sites\/3\/2024\/08\/CZ-tiog-1024x358.png 1024w, https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-content\/uploads\/sites\/3\/2024\/08\/CZ-tiog-300x105.png 300w, https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-content\/uploads\/sites\/3\/2024\/08\/CZ-tiog-768x269.png 768w, https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-content\/uploads\/sites\/3\/2024\/08\/CZ-tiog-600x210.png 600w, https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-content\/uploads\/sites\/3\/2024\/08\/CZ-tiog.png 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong>Nov\u00fd v\u00fdsledek anal\u00fdzy<\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/app.dnaera.sk\/sign-in?&amp;lng=cz\" target=\"_blank\" rel=\"noreferrer noopener\">P\u0159ihlaste se do sv\u00fdch v\u00fdsledk\u016f<\/a>. Nov\u00e1 predispozice je nyn\u00ed zdarma dostupn\u00e1 pro v\u0161echny na\u0161e z\u00e1kazn\u00edky. Z\u00e1rove\u0148 ji bude m\u00edt ve sv\u00e9 anal\u00fdze ka\u017ed\u00fd budouc\u00ed z\u00e1kazn\u00edk, kter\u00fd vstoup\u00ed do sv\u011bta DNA s <a href=\"https:\/\/dnaera.mnt.webikon.sk\/cs\/produkt\/dna-complex-test\/\" target=\"_blank\" rel=\"noreferrer noopener\">DNA Complex testem<\/a> nebo <a href=\"https:\/\/dnaera.mnt.webikon.sk\/cs\/produkt\/dna-health-test\/\" target=\"_blank\" rel=\"noreferrer noopener\">DNA Health testem<\/a>. Poznejte sv\u00e9 predispozice i vy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><strong>Zdroje<\/strong><\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list has-small-font-size\">\n<li>Wang, S., Yuan, X. H., Wang, S. Q., Zhao, W., Chen, X. B., &amp; Yu, B. (2021). FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application. European Journal of Medicinal Chemistry, 214, 113218.<\/li>\n\n\n\n<li>Goh, L. L., Lim, C. W., Leong, K. P., &amp; Ong, K. H. (2022). TPMT and NUDT15 testing for thiopurine therapy: a major tertiary hospital experience and lessons learned. Frontiers in Pharmacology, 13, 837164.<\/li>\n\n\n\n<li><a href=\"https:\/\/www.cancer.gov\/types\/leukemia\/patient\/adult-aml-treatment-pdq\">https:\/\/www.cancer.gov\/types\/leukemia\/patient\/adult-aml-treatment-pdq<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Dok\u00e1\u017eete si p\u0159edstavit molekulu tak malou, \u017ee ji nevid\u00edte, ale tak silnou, \u017ee dok\u00e1\u017ee zm\u011bnit \u017eivot pacienta s onkologick\u00fdm onemocn\u011bn\u00edm? Thioguanin je p\u0159esn\u011b takovou molekulou \u2013 nen\u00e1padn\u00fd a \u00fa\u010dinn\u00fd hrdina v boji proti rakovin\u011b. Abychom v\u0161ak zajistili jeho maxim\u00e1ln\u00ed \u00fa\u010dinnost a minimalizovali riziko ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f, je nezbytn\u00e9 pochopit, jak p\u0159\u00edtomnost r\u016fzn\u00fdch genetick\u00fdch variant v na\u0161\u00ed [&hellip;]<\/p>\n","protected":false},"author":869,"featured_media":1380581,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[58,59],"place-taxonomy":[],"class_list":["post-1380579","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-sk","tag-dna-analyza","tag-dna-test"],"acf":[],"views":1657,"_links":{"self":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1380579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/users\/869"}],"replies":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/comments?post=1380579"}],"version-history":[{"count":1,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1380579\/revisions"}],"predecessor-version":[{"id":1380582,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1380579\/revisions\/1380582"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/media\/1380581"}],"wp:attachment":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/media?parent=1380579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/categories?post=1380579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/tags?post=1380579"},{"taxonomy":"place-taxonomy","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/place-taxonomy?post=1380579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}