{"id":1382177,"date":"2025-03-03T13:38:18","date_gmt":"2025-03-03T12:38:18","guid":{"rendered":"https:\/\/dnaera.mnt.webikon.sk\/cs\/?p=1382177"},"modified":"2025-03-03T13:38:19","modified_gmt":"2025-03-03T12:38:19","slug":"cyp2d6","status":"publish","type":"post","link":"https:\/\/dnaera.mnt.webikon.sk\/cs\/blog\/cyp2d6\/","title":{"rendered":"CYP2D6: Gen, kter\u00fd rozhoduje, zda v\u00e1m tramadol ulev\u00ed od bolesti, nebo ne."},"content":{"rendered":"\n<p><em>Tramadol \u2013 l\u00e9\u010divo, kter\u00e9 m\u016f\u017ee pro n\u011bkoho znamenat okam\u017eitou \u00falevu od bolesti, ale u jin\u00e9ho nezab\u00edr\u00e1. Jak je to mo\u017en\u00e9? Ka\u017ed\u00fd z n\u00e1s reaguje na toto l\u00e9\u010divo odli\u0161n\u011b a pr\u00e1v\u011b tato jedine\u010dnost d\u011bl\u00e1 jeho p\u0159\u00edb\u011bh tak fascinuj\u00edc\u00edm. Tramadol je v\u00edc ne\u017e jen l\u00e9k na zm\u00edrn\u011bn\u00ed bolesti \u2013 je to uk\u00e1zka toho, jak hluboce m\u016f\u017ee genetika ovlivnit \u00fa\u010dinnost l\u00e9\u010dby a pro\u010d je d\u016fle\u017eit\u00e9 zohled\u0148ovat individu\u00e1ln\u00ed rozd\u00edly v DNA.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>O jak\u00e9 l\u00e9\u010divo jde a na co se pou\u017e\u00edv\u00e1?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p>Tramadol pat\u0159\u00ed mezi tzv. opioidn\u00ed analgetika p\u0159edepisovan\u00e1 na zm\u00edrn\u011bn\u00ed st\u0159edn\u011b siln\u00e9 a\u017e siln\u00e9 bolesti. Toto l\u00e9\u010divo nep\u016fsob\u00ed p\u0159\u00edmo na m\u00edsto bolesti, ale na n\u00e1\u0161 mozek a nervov\u00fd syst\u00e9m, kde m\u011bn\u00ed zp\u016fsob, jak\u00fdm bolest vn\u00edm\u00e1me. To z n\u011bj d\u011bl\u00e1 \u00fa\u010dinn\u00e9ho spojence v boji proti nep\u0159\u00edjemn\u00fdm bolestem zp\u016fsoben\u00fdm poopera\u010dn\u00edmi stavy, rakovinou \u010di bolestmi ovliv\u0148uj\u00edc\u00edmi kosti, svaly a klouby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong><strong><strong><strong><strong>Ne ka\u017ed\u00fd metabolizuje toto l\u00e9\u010divo stejn\u011b rychle. Jak\u00fd to m\u016f\u017ee m\u00edt dopad?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p>V souvislosti s metabolismem tramadolu, ale i jin\u00fdch l\u00e9\u010div, se b\u011b\u017en\u011b pou\u017e\u00edvaj\u00ed pojmy:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>standardn\u00ed metaboliz\u00e9r,<\/li>\n\n\n\n<li>slab\u0161\u00ed metaboliz\u00e9r,<\/li>\n\n\n\n<li>slab\u00fd metaboliz\u00e9r.<\/li>\n<\/ul>\n\n\n\n<p>Gen <strong>CYP2D6<\/strong> zaji\u0161\u0165uje tvorbu enzymu, kter\u00fd je odpov\u011bdn\u00fd za p\u0159em\u011bnu tramadolu na jeho aktivn\u00ed formu <strong>M1<\/strong> p\u0159\u00edmo v j\u00e1trech. Tento aktivn\u00ed metabolit m\u00e1 schopnost v\u00e1zat se na receptory v centr\u00e1ln\u00edm nervov\u00e9m syst\u00e9mu, \u010d\u00edm\u017e zabra\u0148uje p\u0159enosu sign\u00e1l\u016f bolesti do zbytku t\u011bla. Krom\u011b toho tramadol ovliv\u0148uje hladiny neurotransmiter\u016f serotoninu a noradrenalinu v mozku. Zabra\u0148uje jejich odbour\u00e1v\u00e1n\u00ed, \u010d\u00edm\u017e zvy\u0161uje jejich koncentraci a zm\u00edr\u0148uje tak pocit bolesti. P\u0159\u00edtomnost r\u016fzn\u00fdch genetick\u00fdch variant v genu <strong>CYP2D6<\/strong> m\u016f\u017ee v\u00e9st k rozd\u00edln\u00e9 aktivit\u011b tohoto enzymu a t\u00edm i k r\u016fzn\u00e9 \u00fa\u010dinnosti tramadolu.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong>Pro\u010d je d\u016fle\u017eit\u00e9 zn\u00e1t tuto predispozici?<\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p>Znalost genetick\u00e9 predispozice pro metabolismus tramadolu je d\u016fle\u017eitou informac\u00ed, kter\u00e1 l\u00e9ka\u0159i umo\u017en\u00ed l\u00e9pe a rychleji optimalizovat u\u017e\u00edv\u00e1n\u00ed tohoto l\u00e9\u010diva a v p\u0159\u00edpad\u011b pot\u0159eby doporu\u010dit jin\u00e9 mo\u017enosti l\u00e9\u010dby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><strong><strong><strong><strong>Nov\u00fd v\u00fdsledek anal\u00fdzy<\/strong><\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n\n<p><a href=\"https:\/\/app.dnaera.com\/sign-in?&amp;lng=cz\" target=\"_blank\" rel=\"noreferrer noopener\">P\u0159ihlaste se <\/a>do sv\u00e9ho \u00fa\u010dtu ve webov\u00e9 aplikaci a pod\u00edvejte se na sv\u016fj v\u00fdsledek. Nov\u00e1 predispozice byla automaticky p\u0159id\u00e1na zdarma v\u0161em na\u0161im sou\u010dasn\u00fdm z\u00e1kazn\u00edk\u016fm. Z\u00e1rove\u0148 ji bude m\u00edt ve sv\u00e9 anal\u00fdze ka\u017ed\u00fd budouc\u00ed z\u00e1kazn\u00edk, kter\u00fd vstoup\u00ed do sv\u011bta DNA s <a href=\"https:\/\/dnaera.mnt.webikon.sk\/cs\/produkt\/dna-complex-test\/\" target=\"_blank\" rel=\"noreferrer noopener\">DNA Complex testem<\/a> nebo <a href=\"https:\/\/dnaera.mnt.webikon.sk\/cs\/produkt\/dna-health-test\/\" target=\"_blank\" rel=\"noreferrer noopener\">DNA Health teste<\/a><a href=\"https:\/\/dnaera.mnt.webikon.sk\/cs\/produkt\/dna-lifestyle-test\/\" target=\"_blank\" rel=\"noreferrer noopener\">m<\/a>. Poznat sv\u00e9 geny m\u00e1 smysl v ka\u017ed\u00e9m v\u011bku. \u010c\u00edm d\u0159\u00edve, t\u00edm l\u00e9pe. Za\u010dn\u011bte objevovat svou DNA i vy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><strong>Zdroje<\/strong><\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list has-small-font-size\">\n<li>Crews, K. R., Monte, A. A., Huddart, R., Caudle, K. E., Kharasch, E. D., Gaedigk, A., &#8230; &amp; Skaar, T. C. (2021). Clinical pharmacogenetics implementation consortium guideline for CYP2D6, OPRM1, and COMT genotypes and select opioid therapy. Clinical Pharmacology &amp; Therapeutics, 110(4), 888-896.<\/li>\n\n\n\n<li>Dean, L., &amp; Kane, M. (2021). Tramadol therapy and CYP2D6 genotype.<\/li>\n\n\n\n<li>Herman, T., Cascella, M., &amp; Muzio, M. R. (2024). Mu Receptors.\u00a0<em>StatPearls<\/em>.<\/li>\n\n\n\n<li>Beakley, B. D., Kaye, A. M., &amp; Kaye, A. D. (2015). Tramadol, pharmacology, side effects, and serotonin syndrome: a review.\u00a0<em>Pain physician<\/em>,\u00a0<em>18<\/em>(4), 395.<\/li>\n\n\n\n<li>Crews, K. R., Monte, A. A., Huddart, R., Caudle, K. E., Kharasch, E. D., Gaedigk, A., &#8230; &amp; Skaar, T. C. (2021). Clinical pharmacogenetics implementation consortium guideline for CYP2D6, OPRM1, and COMT genotypes and select opioid therapy. Clinical Pharmacology &amp; Therapeutics, 110(4), 888-896.<\/li>\n\n\n\n<li><a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/22513-neurotransmitters\">https:\/\/my.clevelandclinic.org\/health\/articles\/22513-neurotransmitters<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Tramadol \u2013 l\u00e9\u010divo, kter\u00e9 m\u016f\u017ee pro n\u011bkoho znamenat okam\u017eitou \u00falevu od bolesti, ale u jin\u00e9ho nezab\u00edr\u00e1. Jak je to mo\u017en\u00e9? Ka\u017ed\u00fd z n\u00e1s reaguje na toto l\u00e9\u010divo odli\u0161n\u011b a pr\u00e1v\u011b tato jedine\u010dnost d\u011bl\u00e1 jeho p\u0159\u00edb\u011bh tak fascinuj\u00edc\u00edm. Tramadol je v\u00edc ne\u017e jen l\u00e9k na zm\u00edrn\u011bn\u00ed bolesti \u2013 je to uk\u00e1zka toho, jak hluboce m\u016f\u017ee genetika [&hellip;]<\/p>\n","protected":false},"author":869,"featured_media":1382178,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"content-type":"","inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[58,59,100,101],"place-taxonomy":[84],"class_list":["post-1382177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-sk","tag-dna-analyza","tag-dna-test","tag-predispozice","tag-zdravi"],"acf":[],"views":2452,"_links":{"self":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1382177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/users\/869"}],"replies":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/comments?post=1382177"}],"version-history":[{"count":1,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1382177\/revisions"}],"predecessor-version":[{"id":1382179,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/posts\/1382177\/revisions\/1382179"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/media\/1382178"}],"wp:attachment":[{"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/media?parent=1382177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/categories?post=1382177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/tags?post=1382177"},{"taxonomy":"place-taxonomy","embeddable":true,"href":"https:\/\/dnaera.mnt.webikon.sk\/cs\/wp-json\/wp\/v2\/place-taxonomy?post=1382177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}